Study of NTproBNP , lipid profile and other conventional risk factors in cardio vascular disease patients

There is lack of data on the relative importance of various conventional risk factors for cardio vascular disease among central Indians. However, cardio vascular disease risk factors have been shown to be more pronounced among diabetes subjects. The NTproBNP has been reported to be elevated in heart failure, ventricular stretch, and pressure overload. We conducted a prospective case-control study to determine the role of NTproBNP in cardio vascular disease among patients with or without diabetes in population of central India.We recruited 100 angio-graphically proven cardio vascular disease patients, 50 with diabetes and 50 without diabetes and 100 case matched controls from patients admitted to our hospital. Demographic, anthropometric measures, NTproBNP, lipids, blood glucose and other conventional risk factors were compared among cases and controls. Univariate and Multivariate analysis were carried out to compare individual factors using t-test, ANOVA and the inter group comparison were done by using Born ferroni Post Hoc tests. The levels of NTproBNP shows a significantly higher values in diabetes with cardio vascular disease patients (n=50, ±SD 1481.021±813.4059, 95% CI 1249.8541712.188) as compared to patients with cardio vascular disease only (n=50, ±SD 704.062±359.269, 95% CI 601.959806.165), diabetic control (n=50, ±SD 37.55±30.72, 95% CI 28.825-46.291) and control (n=50, ±SD 23.56±25.39, 95% CI 16.345-30.779). There is a significant association of NTproBNP with increased age, hyperglycemia, hyperlipidemia, obesity, smoking and hypertension. Conclusion:This study evaluate that NTproBNP is an independent risk predictor of cardio vascular disease, acknowledging limitations resulting from study design, further larger studies are warranted to verify this conclusion in our population. *Corresponding author Phone numbers: +91-07612673645, 09893116236. E-mail adresse:[email protected], [email protected]